Kamada N, Davies H S, Wight D, Culank L, Roser B
Transplantation. 1983 Apr;35(4):304-11.
Orthotopic liver allografts in the rat survive indefinitely without immunosuppressive agents, despite incompatibility between donor and recipient for antigens of the major histocompatibility complex. This is strain-dependent. In the DA to PVG strain combination, liver grafts are never rejected. This is not due to failure of the recipient to mount an immune response against the donor tissue, because there is unequivocal histological evidence of a rejection response during the first few weeks after grafting. This response is moderate and disappears to leave a histologically normal liver, apart from mild bile duct proliferation. Liver function tests show evidence of damage during the phase of cellular infiltration, but these test results also return to normal levels within a few weeks. In the DA to BN strain combination liver grafts are rapidly rejected, and this process is accompanied by histological signs of a violent and progressive destructive cellular response with gross alterations in liver function test results that are progressive until the death of the recipients. F1 hybrid recipients between these two strains (BN X PVG)F1 show intermediate levels of both histological damage and elevated liver function values, but they do not reject their grafts. Recovery from the rejection episode appears to be complete, as judged histologically. However, biochemical values remain slightly elevated, indicating either that the original damage was so severe that it was inconsistent with complete functional recovery or that there is continuous damage that is not visible histologically.
大鼠原位肝同种异体移植物在没有免疫抑制剂的情况下能无限期存活，尽管供体和受体之间在主要组织相容性复合体的抗原方面不相容。这是品系依赖性的。在DA到PVG的品系组合中，肝移植物从不被排斥。这不是因为受体未能对供体组织产生免疫反应，因为在移植后的最初几周有明确的组织学证据表明存在排斥反应。这种反应是适度的，除了轻度胆管增生外，会消失，留下组织学上正常的肝脏。肝功能测试显示在细胞浸润阶段有损伤迹象，但这些测试结果在几周内也会恢复到正常水平。在DA到BN的品系组合中，肝移植物会迅速被排斥，这个过程伴随着剧烈且进行性的破坏性细胞反应的组织学迹象，同时肝功能测试结果有明显变化，这些变化会持续发展直至受体死亡。这两个品系之间的F1杂交受体（BN×PVG）F1在组织学损伤和肝功能值升高方面都处于中间水平，但它们不会排斥移植物。从组织学判断，排斥反应似乎完全恢复。然而，生化值仍略有升高，这表明要么最初的损伤非常严重，以至于与完全的功能恢复不一致，要么存在组织学上不可见的持续损伤。
