[致癌过程中仓鼠颊囊黏膜的细胞形态学研究]
[Cytomorphological study of the mucosa of the hamster cheek pouch in the process of carcinogenesis].
作者信息
Godorozha P D, Zabezhinskiĭ M A, Puchkov Iu G, Pliss G B, Aleksandrov V A
出版信息
Vopr Onkol. 1983;29(2):64-7.
PMID:6404056
Abstract
An 0.5% acetone solution of 7,12-dimethylbenz(a) anthracene was applied to the mucosa of the cheek pouch of 68 Syrian male hamsters. Cytological examination of mucosa samples obtained from the cheek pouch was carried out, and the bioptates and tissues of dead animals were studied histologically. Squamous cell carcinoma of the pouch was identified in 100%. Cytologically-confirmed hyperplasia and dysplasia of the epithelium were found to precede cancer development.
摘要
将7,12 - 二甲基苯并(a)蒽的0.5%丙酮溶液涂抹于68只叙利亚雄性仓鼠颊囊的黏膜上。对从颊囊获取的黏膜样本进行细胞学检查，并对死亡动物的活检组织和组织进行组织学研究。发现100%的颊囊发生了鳞状细胞癌。细胞学证实上皮细胞增生和发育异常先于癌症发生。
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