Bunyaratvej A, Sahaphong S, Bhamarapravati N, Wasi P
Acta Haematol. 1983;69(5):314-8. doi: 10.1159/000206975.
Electron microscopic examination of intraerythrocytic inclusion bodies induced by methylene blue was carried out in 7 non-splenectomized patients with haemoglobin (Hb) H disease. In classical Hb H disease with the genotype of alpha-thalassaemia 1/alpha-thalassaemia 2 the inclusion bodies were mostly membrane-associated. In contrast, in Hb H disease of alpha-thalassaemia 1/Hb Constant Spring genotype the majority of inclusion bodies were in a floating stage. Possible mechanisms for the unexpected difference are discussed.
对7例未行脾切除术的血红蛋白（Hb）H病患者进行了亚甲蓝诱导的红细胞内包涵体的电子显微镜检查。在基因型为α地中海贫血1/α地中海贫血2的典型Hb H病中，包涵体大多与膜相关。相比之下，在α地中海贫血1/Hb Constant Spring基因型的Hb H病中，大多数包涵体处于漂浮阶段。讨论了这种意外差异的可能机制。
