Le Pape A, Gutman N, Guitton J D, Legrand Y, Muh J P
Biochem Biophys Res Commun. 1983 Mar 16;111(2):602-10. doi: 10.1016/0006-291x(83)90349-2.
Pepsin extracted collagen and an acid soluble glycoprotein were purified from placentas of normal and diabetic human beings. Diabetic samples exhibit a significant increase in ketoamine-linked glucose whereas both amino acid and carbohydrate composition were unaffected. This excess non enzymatic condensation of glucose on free amino-groups was found to increase platelet aggregating potency of these proteins independently of any modification in fiber morphology.
从正常人和糖尿病患者的胎盘中提取并纯化了胃蛋白酶提取的胶原蛋白和一种酸溶性糖蛋白。糖尿病样本中酮胺连接的葡萄糖显著增加，而氨基酸和碳水化合物组成未受影响。发现葡萄糖在游离氨基上的这种过量非酶缩合会增加这些蛋白质的血小板聚集能力，而与纤维形态的任何改变无关。
