Hamamoto Y, Hashimoto K, Baba M, Kinoshita K, Yasuhira K
Br J Exp Pathol. 1983 Feb;64(1):93-9.
Endobronchial instillation of Freund's complete adjuvant (FCA) induced plasma-cell granulomas in the lungs of DD strain mice. One week after administration, plasma cells appeared in monolayered cell clusters around pulmonary arterioles running along the bronchial tree. The plasma cells increased in number with time to form granulomas consisting mainly of well developed plasma cells with an admixture of lymphocytes and macrophages. At the peak of production of granulomas (4-10 weeks), the plasma cells piled up around the arterioles and infiltrated the connective tissues surrounding the bronchioles. Germinal-centre-like foci could be demonstrated in the granulomas. The lymph nodes draining the treated lobe showed marked proliferation of plasma cells in the medullary cord, suggesting that the plasma cells passed through alveolar walls into the lung and migrated to periarteriolar connective tissue.
在DD品系小鼠的肺内进行弗氏完全佐剂（FCA）的支气管内滴注可诱导浆细胞性肉芽肿形成。给药一周后，浆细胞出现在沿支气管树分布的肺小动脉周围的单层细胞簇中。随着时间推移，浆细胞数量增加，形成主要由发育良好的浆细胞以及淋巴细胞和巨噬细胞混合组成的肉芽肿。在肉芽肿形成的高峰期（4 - 10周），浆细胞在小动脉周围堆积，并浸润细支气管周围的结缔组织。在肉芽肿中可显示出类似生发中心的病灶。引流处理肺叶的淋巴结在髓索中显示出浆细胞的明显增殖，提示浆细胞穿过肺泡壁进入肺并迁移至动脉周围结缔组织。
