Follézou J Y, Bizon M, Gicquel J
C R Seances Acad Sci III. 1983 Jan 10;296(1):25-8.
Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.
研究了阿霉素在体外对人红细胞的裂解作用,实验分别在pH7的磷酸盐培养基和人血清中进行。药物诱导的溶血现象在浓度显著高于治疗时血浆水平时出现,且血清可显著增强这种溶血作用。这是首次发现人血清因子对阿霉素生物学作用的调节关系。