Shah J P, Feghali J
CA Cancer J Clin. 1983 May-Jun;33(3):154-9. doi: 10.3322/canjclin.33.3.154.
A retrospective review of the clinical records of 31 patients with esthesioneuroblastoma is presented. A bimodal age distribution was noted. The tumor is extremely rare among blacks. Most patients presented with locally advanced disease. However, regional and distant metastases at the time of initial diagnosis are uncommon. Local recurrence at the primary site was very common, and this reflects either the conservative initial surgical treatment employed or the multicentric nature of the tumor. Cervical lymph node metastasis is present in less than 10 percent of patients at the time of diagnosis. The survival rates were better in patients with early stages of disease. From this study, we conclude that the current management of these tumors should consist of a combination of radiation therapy and surgery. Radical resection followed by postoperative radiation therapy appears to be the treatment combination of choice. The five-year survival rate in our series was 52 percent.
本文对31例嗅神经母细胞瘤患者的临床记录进行了回顾性研究。发现年龄分布呈双峰型。该肿瘤在黑人中极为罕见。大多数患者初诊时表现为局部晚期疾病。然而，初诊时出现区域和远处转移并不常见。原发部位的局部复发非常常见，这反映了最初采用的保守手术治疗方式或肿瘤的多中心性质。诊断时不到10%的患者存在颈部淋巴结转移。疾病早期患者的生存率较高。从本研究中，我们得出结论，目前这些肿瘤的治疗应包括放疗和手术相结合。根治性切除术后进行放疗似乎是首选的治疗组合。我们系列研究中的五年生存率为52%。
