枸橼酸乙胺嗪在体外的心肌抑制作用。

Myocardial depressant effects of diethylcarbamazine citrate in vitro.

作者信息

Ojewole J A, Onejeme I V

出版信息

Eur J Pharmacol. 1983 Feb 18;87(2-3):245-52. doi: 10.1016/0014-2999(83)90334-5.

Abstract

The effects of diethylcarbamazine citrate (DECC) have been examined in isolated, electrically driven left atria of guinea-pigs. This anthelmintic drug (DECC, 10(-9) -10(-4) M) produced a sustained, concentration-dependent depression of atrial contractile tension that was reversible by replacing the incubation fluid with DECC-free physiological solution. The negative inotropic response induced by DECC was antagonized in a competitive manner by increasing the calcium ion (Ca2+) concentration of the bathing fluid. On the contrary, the myocardial depressant effects of DECC were antagonized in a non-competitive manner by noradrenaline (NA). The present findings suggest a direct negative inotropic effect of DECC and indicate that this anthelmintic drug interferes with the empirical function of Ca2+ in the events leading to mechanical activity of the isolated atrial myocardium.

摘要

已在豚鼠离体电驱动左心房中研究了枸橼酸乙胺嗪（DECC）的作用。这种驱虫药（DECC，10⁻⁹ - 10⁻⁴ M）可使心房收缩张力持续降低，且呈浓度依赖性，通过用不含DECC的生理溶液替换孵育液可使其逆转。通过增加灌流液中钙离子（Ca²⁺）浓度，DECC诱导的负性肌力反应以竞争性方式被拮抗。相反，去甲肾上腺素（NA）以非竞争性方式拮抗DECC的心肌抑制作用。目前的研究结果表明DECC具有直接的负性肌力作用，并表明这种驱虫药在导致离体心房心肌机械活动的过程中干扰了Ca²⁺的正常功能。