Abaitey A K, Parratt J R
J Pharm Pharmacol. 1977 Jul;29(7):428-32. doi: 10.1111/j.2042-7158.1977.tb11358.x.
The effect of the anthelmintic drug diethylcarbamazine citrate (DECC) was examined on the guinea-pig isolated ileum, rabbit duodenum, chick oesophagus, rat portal vein and pig coronary artery. DECC contracted all the gastrointestinal smooth muscle preparations. The contractions were antagonized by hexamethonium and atropine but they were not affected by mepyramine or methysergide in concentrations that abolished, or markedly reduced, responses to histamine and 5-hydroxytryptamine. DECC inhibited the responses of the guinea-pig ileum to other spasmogens, namely, acetylcholine, histamine and nicotine. Physostigmine markedly potentiated the responses of the chick oesophagus and the rabbit duodenum to DECC. DECC relaxed the potassium chloride-induced contractions of the pig coronary artery strips; these relaxations were not modified by propranolol or calcium chloride. There was no evidence that DECC released histamine from skin or muscle.
研究了抗蠕虫药枸橼酸乙胺嗪（DECC）对豚鼠离体回肠、兔十二指肠、鸡食管、大鼠门静脉和猪冠状动脉的作用。DECC使所有胃肠道平滑肌标本收缩。六甲铵和阿托品可拮抗这些收缩，但在能消除或显著降低对组胺和5-羟色胺反应的浓度下，美吡拉敏或甲基麦角新碱对其无影响。DECC抑制豚鼠回肠对其他致痉剂，即乙酰胆碱、组胺和尼古丁的反应。毒扁豆碱显著增强鸡食管和兔十二指肠对DECC的反应。DECC使猪冠状动脉条氯化钾诱导的收缩松弛；这些松弛不受普萘洛尔或氯化钙的影响。没有证据表明DECC能从皮肤或肌肉中释放组胺。
