Fukutani K, Ishida H, Shinohara M, Minowada S, Niijima T, Isurugi K
Int J Androl. 1983 Feb;6(1):5-11. doi: 10.1111/j.1365-2605.1983.tb00319.x.
Responses of serum testosterone levels to repeated daily injections of 5000 IU hCG for 4 days were studied in 24 patients with Klinefelter's syndrome. Eighteen patients were untreated, and 8 had been given previous treatment with depot testosterone 100 mg intramuscularly every 2-3 weeks for an average duration of 4.7 years. Among them, 4 patients were examined both before and after the therapy. The hCG test was performed at least 2 weeks (0.5-12 months) after the last injection of depot testosterone in the treated patients. Mean basal testosterone level of the treated patients, 139 +/- 98 ng/dl (Mean +/- SD), was not significantly different from that of the untreated patients, 172 +/- 110 ng/dl. Maximum stimulated testosterone level in the treated patients, 170 +/- 107 ng/dl (P less than 0.05). These results suggest that long-term androgen administration may decrease the functional reserve of Leydig cells in patients with Klinefelter's syndrome.
对24例克兰费尔特综合征患者进行了研究，观察他们在连续4天每日注射5000国际单位人绒毛膜促性腺激素（hCG）后血清睾酮水平的反应。18例患者未接受过治疗，8例曾接受过治疗，此前每2 - 3周肌肉注射长效睾酮100毫克，平均疗程为4.7年。其中，4例患者在治疗前后均接受了检查。在接受治疗的患者中，hCG检测在最后一次注射长效睾酮后至少2周（0.5 - 12个月）进行。接受治疗患者的平均基础睾酮水平为139±98纳克/分升（平均值±标准差），与未接受治疗患者的172±110纳克/分升无显著差异。接受治疗患者的最大刺激睾酮水平为170±107纳克/分升（P＜0.05）。这些结果表明，长期雄激素给药可能会降低克兰费尔特综合征患者睾丸间质细胞的功能储备。
