Ray G R, Fish V J, Lee R H, Marzoni F A, Trollope M L, Hews M, Gribble M
Int J Radiat Oncol Biol Phys. 1983 Jan;9(1):23-8. doi: 10.1016/0360-3016(83)90203-1.
One hundred-twenty patients with Stages I and II carcinoma of the female breast were treated by biopsy followed by definitive radiation therapy without mastectomy. The breast received 4500-5000 cGy (rad) using a 6 MV linear accelerator followed by a supplement to the area of the primary tumor of 2000 cGy (rad) using electrons in 99 patients (83%) and interstitial implantation in 21 patients (17%). Local recurrence was not recorded in the 43 patients with Stage I disease, while three of 77 patients (4%) with Stage II disease suffered a local recurrence. The actuarial five-year relapse-free survival was 91% and 60% in Stages I and II respectively. Cosmetic results were considered excellent by both physician and patient in the majority of cases. Axillary dissection was the recommended method of staging the axilla but was noted to be more morbid than axillary sampling. Electrons may be as effective as interstitial implantation as a means of supplementation following external beam therapy if specific guidelines are followed.
120例I期和II期女性乳腺癌患者接受了活检，随后进行了保乳根治性放射治疗。使用6兆伏直线加速器对乳房给予4500 - 5000厘戈瑞（拉德）的剂量，随后对99例患者（83%）的原发肿瘤区域补充2000厘戈瑞（拉德）的电子线照射，21例患者（17%）采用组织间插植放疗。43例I期疾病患者未记录到局部复发，而77例II期疾病患者中有3例（4%）出现局部复发。I期和II期患者的精算五年无复发生存率分别为91%和60%。在大多数病例中，医生和患者都认为美容效果极佳。腋窝清扫术是推荐的腋窝分期方法，但被指出比腋窝取样的创伤更大。如果遵循特定指南，电子线照射作为外照射后的补充手段可能与组织间插植放疗一样有效。
