Biggins J A, Perry E K, McDermott J R, Smith A I, Perry R H, Edwardson J A
J Neurol Sci. 1983 Jan;58(1):117-22. doi: 10.1016/0022-510x(83)90114-4.
The levels of neurotensin and thyrotropin-releasing hormone (TRH) in normal post mortem human amygdala have been compared with those in cases of schizophrenia, Alzheimer's disease and depression. Amongst various factors which can influence post mortem human brain biochemistry (including age, sex, post mortem delay, time of death, disease status and severity), sex difference appeared to be responsible for the most extensive variation. The levels of both peptides were nearly doubled in males compared with females and this increase was significant in the case of neurotensin. There was also a positive correlation between neurotensin and TRH levels. Although levels of neurotensin and TRH tended to be lower in the disease groups these trends did not reach significance.
已将正常人类杏仁核尸检样本中的神经降压素和促甲状腺激素释放激素（TRH）水平，与精神分裂症、阿尔茨海默病和抑郁症患者的样本进行了比较。在可影响人类大脑尸检生物化学的各种因素中（包括年龄、性别、尸检延迟、死亡时间、疾病状态和严重程度），性别差异似乎是造成最广泛变化的原因。与女性相比，男性体内这两种肽的水平几乎翻倍，且神经降压素水平的这种升高具有显著性。神经降压素和TRH水平之间也存在正相关。尽管疾病组中神经降压素和TRH水平往往较低，但这些趋势并不显著。
