Perry R H, Dockray G J, Dimaline R, Perry E K, Blessed G, Tomlinson B E
J Neurol Sci. 1981 Sep;51(3):465-72. doi: 10.1016/0022-510x(81)90123-4.
Vasoactive intestinal peptide (VIP) and cholecystokinin (CCK) have been measured, by radioimmunoassay, in cerebral cortex obtained at autopsy from patients without neurological or psychiatric disease and from patients with Alzheimer's disease, depression and schizophrenia. Sephadex gel filtration indicated that over 90% of the CCK immunoreactivity was associated with the octapeptide in extracted material from the different clinical groups investigated. There were no significant differences from the normal in the overall concentrations of either VIP or CCK in any of the psychiatric groups examined, although differences in Alzheimer's disease were apparent when cases were grouped according to postmortem delay.
通过放射免疫测定法，对无神经或精神疾病患者以及患有阿尔茨海默病、抑郁症和精神分裂症的患者尸检时获取的大脑皮层中的血管活性肠肽（VIP）和胆囊收缩素（CCK）进行了测量。葡聚糖凝胶过滤表明，在所研究的不同临床组的提取物中，超过90%的CCK免疫反应性与八肽相关。在所检查的任何精神疾病组中，VIP或CCK的总体浓度与正常情况均无显著差异，不过，根据死后延迟时间对阿尔茨海默病病例进行分组时，差异较为明显。
