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砷对大鼠发育中大脑的影响(作者译)

[Effect of arsenic on the developing brain of rat (author's transl)].

作者信息

Tamura S

出版信息

Nihon Yakurigaku Zasshi. 1978 Jan;74(1):1-14.

PMID:640531
Abstract

An experiment was conducted in an attempt to determine the effect of arsenic on body weight, brain weight and brain chemical composition in suckling rats. Four hundred and ninety-nine young rats from Wistar albino mothers in a closed colony (TAMURA, 1950) were grouped into four according to the treatment given. Group 1 served as control. Rats in Group II were treated with As2O3 1.5 mg/kg, those in Group III 15 mg/kg and those in Group IV arsenic compounds (corresponding 15 mg/kg of As2O3) for 7 to 21 days after birth. Measurements were recorded for 3 to 15 weeks. The mortality of groups I and II was approximately 10%, while that of groups III and IV was approximately 50%. Regarding body weight, brain weight and brain chemical composition of provision of the same, there was no significant difference between controls and the arsenic treated males and females under conditions Oriental feed diet and powdered milk.

摘要

进行了一项实验,试图确定砷对乳鼠体重、脑重和脑化学成分的影响。来自封闭种群中Wistar白化病母亲的499只幼鼠(田村,1950年)根据所给予的处理分为四组。第1组作为对照。第II组的大鼠在出生后7至21天用1.5毫克/千克的三氧化二砷处理,第III组用15毫克/千克处理,第IV组用砷化合物(相当于15毫克/千克的三氧化二砷)处理。在3至15周内记录测量结果。第I组和第II组的死亡率约为10%,而第III组和第IV组的死亡率约为50%。关于体重、脑重和脑化学成分的供应情况,在东方饲料和奶粉条件下,对照组与经砷处理的雄性和雌性之间没有显著差异。

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