Edwards F, Schabinsky V V, Jackson D M, Starmer G A, Jenkins O
Psychopharmacology (Berl). 1983;79(2-3):246-50. doi: 10.1007/BF00427821.
The percentage of mice able to remain on a rolling drum for 45 s was recorded at 1.25 min and 30 min after administration of ethanol (2.4 g/kg). Though there was no significant difference in brain ethanol levels at the two test times, performance was markedly different with significantly fewer mice able to remain on the drum at 1.25 min than at 30 min. This phenomenon, known as acute tolerance, was antagonised by pretreating mice with haloperidol (0.4 mg/kg), FLA-63 (25 mg/kg), diethyldithiocarbamate (400 mg/kg), phenoxybenzamine (40 mg/kg), phentolamine (20 mg/kg), yohimbine (3 mg/kg) and clozapine (1 mg/kg), but not by spiperone (0.16 mg/kg), alpha-methyl-p-tyrosine (300 mg/kg) or phenobarbitone (10 mg/kg). The relative potencies of the effective blocking agents suggest that alpha 2-receptors may play an important role in mediating acute ethanol tolerance.
在给予乙醇（2.4克/千克）后1.25分钟和30分钟时，记录能够在滚动鼓上停留45秒的小鼠百分比。虽然在两个测试时间点大脑中的乙醇水平没有显著差异，但表现却明显不同，在1.25分钟时能够留在鼓上的小鼠明显少于30分钟时。这种现象称为急性耐受性，用氟哌啶醇（0.4毫克/千克）、FLA - 63（25毫克/千克）、二乙基二硫代氨基甲酸盐（400毫克/千克）、酚苄明（40毫克/千克）、酚妥拉明（20毫克/千克）、育亨宾（3毫克/千克）和氯氮平（1毫克/千克）预处理小鼠可对抗这种现象，但螺哌隆（0.16毫克/千克）、α-甲基对酪氨酸（300毫克/千克）或苯巴比妥（10毫克/千克）则不能。有效阻断剂的相对效力表明α2受体可能在介导急性乙醇耐受性中起重要作用。
