Härle A, Ritzerfeld W, Wiynck G, Knoche U
Z Orthop Ihre Grenzgeb. 1983 Jan-Feb;121(1):6-9. doi: 10.1055/s-2008-1051306.
The corresponding levels of azlocillin in serum and in synovial fluid in the knee-joint were investigated in patients who had undergone aseptic surgery of the lower limbs. The mean synovial fluid concentrations for azlocillin were determined on the basis of 30 samples. Clinically relevant azlocillin levels of approximately 40 mu g/ml were recorded in synovial fluid 10 minutes after start of a short infusion of 5 gm. These increased until about 90 minutes after commencement of antibiotic administration when the maximum level was attained. Subsequently synovial fluid levels decreased slowly and approximately 170 minutes after commencement of the short infusion the mean for serum and synovial concentrations corresponded. The results confirm that with an i.v. infusion of 5 g azlocillin levels can be attained for 3 hours in the synovial fluid that are above the break-point for this antibiotic of 64 mu g/ml. However, despite these good pharmacokinetic data it should be remembered that experience has shown that surgical reintervention is often necessary in addition in joint infections to achieve ultimate cure.
对接受下肢无菌手术的患者，研究了其血清和膝关节滑液中阿洛西林的相应水平。基于30份样本测定了阿洛西林在滑液中的平均浓度。在快速输注5克阿洛西林开始10分钟后，滑液中记录到约40微克/毫升的临床相关阿洛西林水平。这些水平持续上升，直至抗生素给药开始约90分钟后达到最高水平。随后，滑液水平缓慢下降，在快速输注开始约170分钟后，血清和滑液浓度的平均值相对应。结果证实，静脉输注5克阿洛西林时，滑液中可在3小时内达到高于该抗生素64微克/毫升断点的水平。然而，尽管有这些良好的药代动力学数据，但应记住，经验表明，在关节感染中，除了这些治疗外，往往还需要再次进行手术干预才能实现最终治愈。
