Domschke W
Fortschr Med. 1978 Apr 13;96(14):739-42.
In medical practice, diagnostic and therapeutic aspects of gastrointestinal hormones attract interest. Gastrin--in the form of pentagastrin--can be used for gastric secretory analysis and, in the analysis of exocrine pancreatic function, secretin and cholecystokinin-pancreozymin can be employed as stimulants. Diagnosis of hormone-producing tumors is possible by radioimmunological determination of serum levels of the hormone in question: so, dramatically high gastrin levels can be found in the Zollinger-Ellison syndrome while in the Verner-Morrison syndrome, VIP (vasoactive intestinal peptide) values are significantly elevated.--The therapeutic use of gastrointestinal hormones (gastrin, secretin) is waiting in the wings.
在医学实践中,胃肠激素的诊断和治疗方面备受关注。胃泌素(以五肽胃泌素的形式)可用于胃液分泌分析,在胰腺外分泌功能分析中,促胰液素和缩胆囊素-促胰酶素可作为刺激剂。通过放射免疫法测定血清中相关激素水平,有可能诊断出激素分泌肿瘤:因此,在佐林格-埃利森综合征中可发现胃泌素水平急剧升高,而在韦纳-莫里森综合征中,血管活性肠肽(VIP)值则显著升高。——胃肠激素(胃泌素、促胰液素)的治疗用途尚有待开发。