Abou-Saleh M T, Coppen A
Br J Psychiatry. 1983 Apr;142:391-7. doi: 10.1192/bjp.142.4.391.
The prevalence of subjective side-effects was studied in 258 control subjects, 65 drug-free depressive in-patients and 94 lithium-treated out-patients. It was shown that drug-free depressives reported more side-effects than both control subjects and lithium-treated patients. Side-effects were studied during amitriptyline therapy. Depressed patients on no medication complained of only slightly fewer side-effects than when they had received amitriptyline. There was a significant positive correlation of Hamilton depression scores and side-effects scores at baseline. Side-effects and affective morbidity over two years were investigated in 94 patients with recurrent affective disorders on long-term lithium therapy. Psychological variables were also investigated in 74 of these patients. Subjective side-effects reported by lithium-treated patients including those specific to lithium were related to their affective morbidity and personality variables. Patients on lithium complained significantly less of headache and unilateral headache than controls.
对258名对照受试者、65名未服用药物的抑郁症住院患者和94名接受锂治疗的门诊患者的主观副作用发生率进行了研究。结果显示，未服用药物的抑郁症患者报告的副作用比对照受试者和接受锂治疗的患者都多。在阿米替林治疗期间对副作用进行了研究。未服用药物的抑郁症患者抱怨的副作用仅比服用阿米替林时略少。基线时汉密尔顿抑郁评分与副作用评分之间存在显著正相关。对94名长期接受锂治疗的复发性情感障碍患者进行了两年的副作用和情感发病率调查。还对其中74名患者的心理变量进行了研究。接受锂治疗的患者报告的主观副作用，包括锂特有的副作用，与他们的情感发病率和人格变量有关。服用锂的患者抱怨头痛和单侧头痛的情况明显少于对照组。
