Bocchetta A, Bernardi F, Burrai C, Pedditzi M, Del Zompo M
Department of Neuroscience Bernard B. Brodie, University of Cagliari, Italy.
Acta Psychiatr Scand. 1993 Dec;88(6):434-9. doi: 10.1111/j.1600-0447.1993.tb03487.x.
A double-blind group comparison study of L-sulpiride and amitriptyline was carried out in 30 bipolar outpatients on maintenance treatment with lithium suffering from a major depressive recurrence. L-sulpiride showed equivalent antidepressant activity to amitriptyline at 4 weeks using the Hamilton Rating Scale for Depression. However, the onset of action was faster in the L-sulpiride group, showing a significant improvement at 1 week in both anxiety-somatization and specific depression items, including depressed mood, feelings of guilt, work & activities and retardation. The incidence of anticholinergic side effects was significantly higher in the amitriptyline treatment group.
对30名正在接受锂盐维持治疗且出现重度抑郁复发的双相情感障碍门诊患者进行了一项关于L-舒必利和阿米替林的双盲组间比较研究。使用汉密尔顿抑郁量表评估发现，在4周时L-舒必利显示出与阿米替林相当的抗抑郁活性。然而，L-舒必利组的起效更快，在1周时焦虑-躯体化及特定抑郁项目（包括情绪低落、内疚感、工作与活动及迟缓）均有显著改善。阿米替林治疗组抗胆碱能副作用的发生率显著更高。
