多沙普仑对正常人的通气作用。

The ventilatory effects of doxapram in normal man.

Calverley P M, Robson R H, Wraith P K, Prescott L F, Flenley D C

Clin Sci (Lond). 1983 Jul;65(1):65-9. doi: 10.1042/cs0650065.

Abstract

To determine the mode of action of doxapram in man we have measured ventilation, oxygen uptake, CO2 production, hypoxic and hypercapnic ventilatory responses in six healthy men before and during intravenous infusion to maintain a constant plasma level. 2. Doxapram changed neither resting oxygen uptake nor CO2 production but produced a substantial increase in resting ventilation at both levels of end-tidal CO2 studied. 3. Doxapram increased the ventilatory response to isocapnic hypoxia from -0.8 +/- 0.4 litre min-1 (%SaO2)-1 to -1.63 +/- 0.9 litres min-1 (%SaO2)-1. This was similar to the increase in hypoxic sensitivity which resulted from raising the end-tidal CO2 by 0.5 kPa without adding doxapram. 4. The slope of the ventilatory response to rebreathing CO2 rose from 11.6 +/- 5.3 litres min-1 kPa-1 to 20.4 +/- 9.8 litres min-1 kPa-1 during doxapram infusion. 5. The marked increase in the ventilatory response to CO2 implies that doxapram has a central action, but the potentiation of the hypoxic drive also suggests that the drug acts on peripheral chemoreceptors, or upon their central connections, at therapeutic concentrations in normal unanaesthetized subjects.

摘要

为了确定多沙普仑在人体中的作用方式，我们在六名健康男性静脉输注药物以维持血浆浓度恒定之前和期间，测量了他们的通气量、氧气摄取量、二氧化碳生成量、低氧和高碳酸血症通气反应。2. 多沙普仑既未改变静息状态下的氧气摄取量，也未改变二氧化碳生成量，但在研究的两个呼气末二氧化碳水平上，均使静息通气量显著增加。3. 多沙普仑使对等碳酸血症性低氧的通气反应从-0.8±0.4升·分钟⁻¹（%血氧饱和度）⁻¹增加至-1.63±0.9升·分钟⁻¹（%血氧饱和度）⁻¹。这与在不添加多沙普仑的情况下将呼气末二氧化碳升高0.5千帕所导致的低氧敏感性增加相似。4. 在输注多沙普仑期间，对重复呼吸二氧化碳的通气反应斜率从11.6±5.3升·分钟⁻¹千帕⁻¹升至20.4±9.8升·分钟⁻¹千帕⁻¹。5. 对二氧化碳通气反应的显著增加表明多沙普仑具有中枢作用，但低氧驱动的增强也表明该药物在正常未麻醉受试者的治疗浓度下作用于外周化学感受器或其与中枢的联系。