Davidson J, Miller R, Van Wyck Fleet J, Strickland R, Manberg P, Allen S, Parrott R
J Clin Psychiatry. 1983 May;44(5 Pt 2):115-7.
Bupropion and amitriptyline were compared in a double-blind study of depressed inpatients. Treatment ranged from 2 to 4 weeks: early responders (Hamilton Depression Scale scores less than 10) were often removed from treatment after 2 or 3 weeks. Twenty-two patients completed treatment with bupropion and 18 with amitriptyline. Doses ranged from 450 to 750 mg/day for bupropion and 75 to 225 mg/day for amitriptyline. Overall, bupropion and amitriptyline were equally effective, as measured by the Hamilton Depression and Anxiety scales, Clinical Global Impressions, Zung Depression scale, and the SCL-90. Differences in the side effect profile and in weight change are described.
在一项针对住院抑郁症患者的双盲研究中，对安非他酮和阿米替林进行了比较。治疗时间为2至4周：早期有反应者（汉密尔顿抑郁量表评分低于10分）常在2或3周后停止治疗。22名患者完成了安非他酮治疗，18名患者完成了阿米替林治疗。安非他酮的剂量范围为每日450至750毫克，阿米替林为每日75至225毫克。总体而言，根据汉密尔顿抑郁与焦虑量表、临床总体印象量表、zung抑郁量表和症状自评量表90项结果评估，安非他酮和阿米替林的疗效相当。文中描述了两者在副作用和体重变化方面的差异。
