对植入大鼠腺胃的吉田肉瘤腹水细胞的化疗研究。5-氟尿嘧啶、甲环亚硝脲、丝裂霉素C、阿霉素和阿糖胞苷的单一疗法，以及各自的两药联合疗法。
Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combinations.
作者信息
Eichler G, Habs M, Schmähl D
出版信息
J Cancer Res Clin Oncol. 1983;105(3):250-7. doi: 10.1007/BF00395753.
Abstract
The chemotherapeutic activity of five cytostatic drugs was investigated experimentally in monotherapy and in two-drug combinations, using Yoshida sarcoma cells implanted into the wall of the glandular stomach of Sprague-Dawley rats. In monotherapy, the antibiotic agent mitomycin C and the nitrosourea methyl-CCNU exhibited the highest cytotoxic activity in this tumor model. In combination therapy, the combination of these two drugs was superior to all the other therapeutic schemes tested. In general, the results demonstrate a marked superiority of combination therapy in comparison with monotherapy.
摘要
使用接种于斯普拉格-道利大鼠腺胃壁的吉田肉瘤细胞，对五种细胞毒性药物的化疗活性进行了单药治疗及两药联合治疗的实验研究。在单药治疗中，抗生素丝裂霉素C和亚硝基脲甲环亚硝脲在该肿瘤模型中表现出最高的细胞毒性活性。在联合治疗中，这两种药物的联合优于所有其他测试的治疗方案。总体而言，结果表明联合治疗相对于单药治疗具有明显优势。
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Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combinations.对植入大鼠腺胃的吉田肉瘤腹水细胞的化疗研究。5-氟尿嘧啶、甲环亚硝脲、丝裂霉素C、阿霉素和阿糖胞苷的单一疗法，以及各自的两药联合疗法。
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