Preputial tumors induced by intragastric intubations of 7,12-dimethylbenz(a)anthracene in gonadectomized female and male rats.

A series of administrations of 7,12-dimethylbenz(a)anthracene given at biweekly intervals by gastric intubation to gonadectomized rats of the Sprague-Dawley strain elicited a considerable number of preputial tumors. The tumors commonly consisted of solid and cystic parts with a wide variety of histologic features and were classified as adenomas, carcinomas, and malignant mixed tumors.