Hardin B D, Schuler R L, McGinnis P M, Niemeier R W, Smith R J
Mutat Res. 1983 May-Jun;117(3-4):337-44. doi: 10.1016/0165-1218(83)90133-7.
Propylene oxide (CAS No. 75-56-9) was tested for mutagenic activity following vapor exposure using 3 in vivo test systems. Rat dominant lethal and mouse sperm-head morphology assays were conducted using males exposed to propylene oxide at 300 ppm in a dynamic exposure chamber for 7 h per day on 5 consecutive days. A sex-linked recessive lethal test in Drosophila melanogaster employed a 24-h static exposure to propylene oxide at 645 ppm. Male mice were killed 1, 3, 5, 7, and 9 weeks post-exposure for evaluation of sperm-head morphology. Propylene oxide exposure did not result in an increase in abnormal forms. Male rats were mated with 2 virgin females per week for 6 weeks following exposure. A statistically significant increase in preimplantation losses and a statistically significant reduction in the number of living implants in the first post-exposure week did not appear to be treatment related. A highly significant increase in sex-linked recessive lethal mutations was observed in two germ cell stages (mature sperm and developing spermatocytes). These results warrant continued caution in potential human exposure to propylene oxide.
环氧丙烷（化学物质登记号：75-56-9）采用3种体内测试系统，对其蒸汽暴露后的致突变活性进行了测试。对雄性大鼠进行显性致死试验以及对雄性小鼠进行精子头部形态分析，雄性动物置于动态暴露舱中，以300 ppm的浓度暴露于环氧丙烷，每天暴露7小时，连续暴露5天。在果蝇中进行性连锁隐性致死试验，采用645 ppm的环氧丙烷进行24小时静态暴露。在暴露后1、3、5、7和9周处死雄性小鼠，以评估精子头部形态。环氧丙烷暴露并未导致异常形态增加。暴露后，雄性大鼠每周与2只未交配过的雌性大鼠交配，持续6周。在暴露后的第一周，着床前损失出现统计学显著增加，存活胚胎数量出现统计学显著减少，但这似乎与处理无关。在两个生殖细胞阶段（成熟精子和发育中的精母细胞）观察到性连锁隐性致死突变显著增加。这些结果表明，对于人类潜在接触环氧丙烷的情况仍需持续保持谨慎。
