[Concentration of lipids and apolipoproteins A-1 and E in blood plasma of men with acute alcohol intoxication].

Content of lipids and apolipoproteins A-1 and E was studied in blood plasma of men with acute alcohol intoxication as well as within 10-12 hrs after their treatment in a special clinic. Acute alcohol intoxication caused a distinct increase of triglycerides as well as of cholesterol in high and very low density lipoproteins simultaneously with decrease in content of cholesterol in low density lipoproteins. At the same time, content of apolipoprotein A-1 was increased and of apo E--unaltered. Within 12 hrs after treatment of the men concentrations of triglycerides and cholesterol of very low density lipoproteins became quite normal but the other patterns studied did not alter. Alcohol appears to affect the distribution of cholesterol between individual lipoprotein fractions in blood. This process depended distinctly on alteration of apo A-1 concentration in blood plasma.