抗抑郁药物对心脏的影响。三环类抗抑郁药与氟伏沙明的比较。
Cardiac effects of antidepressant drugs. A comparison of the tricyclic antidepressants and fluvoxamine.
作者信息
Roos J C
出版信息
Br J Clin Pharmacol. 1983;15 Suppl 3(Suppl 3):439S-445S. doi: 10.1111/j.1365-2125.1983.tb02135.x.
Abstract
1 The cardiovascular effects of the tricyclic antidepressants (TCAs) are reviewed and compared with those of fluvoxamine, a new 5-hydroxytryptamine (5-HT) re-uptake inhibitor. 2 The TCAs have important effects on the heart, related to their anticholinergic and quinidine-like properties. The major side effects in therapeutic dosage include heart rate increase, postural hypotension and slight prolongation of the intraventricular conduction time and QT interval. In toxic dosage (or normal dosage in patients with severe heart disease) both advanced heart block and ventricular arrhythmias can occur, together with clinically important loss of myocardial contractile force. 3 Fluvoxamine has no effects on the heart except for a statistically (but not clinically) significant slowing of the heart rate.
摘要
- 本文综述了三环类抗抑郁药（TCAs）的心血管效应，并与新型5-羟色胺（5-HT）再摄取抑制剂氟伏沙明的心血管效应进行了比较。2. TCAs对心脏有重要影响，这与其抗胆碱能和奎尼丁样特性有关。治疗剂量下的主要副作用包括心率加快、体位性低血压以及室内传导时间和QT间期轻度延长。在中毒剂量（或重症心脏病患者的正常剂量）下，可发生高度心脏传导阻滞和室性心律失常，同时伴有临床上重要的心肌收缩力丧失。3. 氟伏沙明对心脏无影响，只是心率有统计学意义（但无临床意义）的减慢。
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