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[杜兴氏肌营养不良症携带者检测中平均纤维密度(单纤维导联)、定量肌电图及血清肌酸激酶的测定]

[Determination of average fiber density (single fiber lead), quantitative electromyography and serum CK in the detection of Duchenne carriers].

作者信息

Mamoli B, Toifl K, Vormittag W, Pateisky K

出版信息

EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb. 1983 Mar;14(1):36-8.

PMID:6407816
Abstract

The fibre density of the extensor digitorum communis muscle was examined with a monopolar single fiber electrode in 2 definite, one probable and 15 possible Duchenne-carriers. In addition serum-CK was evaluated three times in intervals of a least one week. The fibre density was increased in one definite, one probable and 4 possible carriers (greater than 1.6). The highest value was 2.0. Excepting one case the increase of fibre density was accompanied by an increase of serum-CK (greater than 60 mg%). The highest value of CK was 1626 mg%. The conventional EMG was pathological in 2 cases. In no case with an increase of CK or with pathological EMG the fibre density was normal. The fibre density is an unspecific but rather sensible indicator of Duchenne-carriers but as we could observe in a definite carrier, negative results do not exclude carriers.

摘要

使用单极单纤维电极对2例确诊、1例疑似和15例可能的杜兴氏携带者的指总伸肌纤维密度进行了检测。此外,每隔至少一周对血清肌酸激酶(CK)进行三次评估。1例确诊、1例疑似和4例可能的携带者的纤维密度增加(大于1.6)。最高值为2.0。除1例外,纤维密度增加的同时血清CK也升高(大于60mg%)。CK的最高值为1626mg%。2例患者的常规肌电图检查结果异常。在CK升高或肌电图检查结果异常的病例中,纤维密度均未正常。纤维密度是杜兴氏携带者的一个非特异性但相当敏感的指标,但正如我们在1例确诊携带者中观察到的,阴性结果并不能排除携带者。

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