Holmes E J, Jacobson S, Stein B M, Butters N
Exp Neurol. 1983 Jul;81(1):97-113. doi: 10.1016/0014-4886(83)90160-7.
A new procedure was developed for ablating the mammillary nuclei in nonhuman primates via direct visual exposure. Using this technique, monkeys receiving lesions of the mammillary nuclei were compared to control animals after surgery to assess the retention of preoperatively acquired visuospatial discriminations and subsequent postoperative ability to attain a demanding spatial memory task. Although the lesions proved to be accurate and complete, no changes in gross behavior or deficits in preoperatively acquired visual and spatial behaviors were noted. The monkeys with mammillary body lesions were, however, impaired in their ability to acquire postoperatively the demanding spatial memory task. These findings are consistent with previous investigations suggesting that the mammillary bodies are involved in the acquisition of spatial discriminations and skills.
一种通过直接视觉暴露在非人类灵长类动物中消融乳头体核的新方法被开发出来。使用这种技术，将接受乳头体核损伤的猴子与术后的对照动物进行比较，以评估术前获得的视觉空间辨别能力的保留情况以及术后完成一项具有挑战性的空间记忆任务的能力。尽管损伤被证明是准确和完整的，但未观察到总体行为的变化或术前获得的视觉和空间行为的缺陷。然而，患有乳头体损伤的猴子在术后完成具有挑战性的空间记忆任务的能力上受到损害。这些发现与先前的研究一致，表明乳头体参与空间辨别和技能的获得。
