Sziklas V, Petrides M
Department of Psychology, McGill University, Quebec, Canada.
Eur J Neurosci. 1993 May 1;5(5):525-40. doi: 10.1111/j.1460-9568.1993.tb00518.x.
The contribution of the mammillary region to learning and memory was investigated. It was demonstrated that lesions of this region impair performance on tasks that require memory for spatial information but that the deficit depends both on the amount of damage within the region and the difficulty of the task. A dissociation in the effect of such lesions on performance of comparable spatial and non-spatial memory tasks was shown. In contrast to the deficits observed on spatial memory tasks, the acquisition and retention of a complex non-spatial memory task was not impaired after extensive damage to the mammillary region. Such lesions also did not impair performance in a conditioned taste aversion task. These experiments suggest that the mammillary region may be selectively involved in spatial learning and memory.
研究了乳头体区域对学习和记忆的贡献。结果表明，该区域的损伤会损害需要对空间信息进行记忆的任务的表现，但这种缺陷既取决于该区域内损伤的程度，也取决于任务的难度。研究显示了此类损伤对类似空间和非空间记忆任务表现的影响存在分离。与在空间记忆任务中观察到的缺陷相反，在乳头体区域受到广泛损伤后，复杂非空间记忆任务的习得和保持并未受损。此类损伤也未损害条件性味觉厌恶任务的表现。这些实验表明，乳头体区域可能选择性地参与空间学习和记忆。
