Abdo K M, Haseman J K, Boorman G, Farnell D R, Prejean J D, Kovatch R
Food Chem Toxicol. 1983 Jun;21(3):259-62. doi: 10.1016/0278-6915(83)90058-3.
Diets containing 2.5 or 5% D-mannitol were fed to groups of 50 F344 rats and 50 B6C3F1 mice of each sex for 103 wk. Similar groups served as controls. There were no significant differences in survival between treated and control rats or between treated and control mice. Mean body weights were similar in treated and control male rats and in treated and control female mice. Throughout the study, the mean body weights of female rats on the 5% diet were slightly (less than 10%) lower than those of the controls, and by the end of the study the mean body weights of treated male mice were slightly (c. 10%) higher than those of the controls. Feed consumption by treated and control animals was approximately the same in rats and mice of either sex. The incidence of dilation of the gastric fundal gland was higher (46%) in treated female rats than in the controls (12%). A mild nephrosis, characterized by focal vacuolization of the renal tubular epithelium, showed an increased incidence in treated mice of both sexes and was considered to be related to the administration of D-mannitol. There were no statistically significant increases in tumour incidence in any of the treated groups when compared with the corresponding controls. Under the conditions of this bioassay, D-mannitol was not shown to be carcinogenic for F344 rats or B6C3F1 mice of either sex.
将含2.5%或5%D-甘露醇的饲料分别喂给每组50只不同性别的F344大鼠和50只B6C3F1小鼠，持续103周。类似的组作为对照组。处理组与对照组大鼠之间以及处理组与对照组小鼠之间的存活率无显著差异。处理组和对照组的雄性大鼠以及处理组和对照组的雌性小鼠的平均体重相似。在整个研究过程中，食用5%饲料的雌性大鼠的平均体重略低于对照组（低于10%），到研究结束时，处理组雄性小鼠的平均体重略高于对照组（约10%）。处理组和对照组动物的采食量在不同性别的大鼠和小鼠中大致相同。处理组雌性大鼠胃底腺扩张的发生率高于对照组（46%对12%）。一种以肾小管上皮局灶性空泡化为特征的轻度肾病，在处理组的两性小鼠中发生率均增加，被认为与D-甘露醇的给药有关。与相应的对照组相比，任何处理组的肿瘤发生率均无统计学上的显著增加。在本生物测定条件下，未显示D-甘露醇对不同性别的F344大鼠或B6C3F1小鼠具有致癌性。
