Robb R M, Silver J, Sullivan R T
Invest Ophthalmol Vis Sci. 1978 May;17(5):468-73.
The ocular retardation (or) mutation in mice has been studied morphologically in serial 1 mu sections. This recessively inherited, fully penetrant mutation is characterized by an early arrest of retinal development, aplasia of the optic nerve, cataractous degeneration of the lens, and microphthalmia. We describe early alterations of normally occurring morphogenetic cell death in the optic cup and aberrations of optic fissure formation which appear to precede the arrest of retinal and optic nerve development. The subsequent disappearance of central retinal vessels and cataract formation are interpreted as secondary phenomena.
已在连续1微米切片上对小鼠的眼发育迟缓（or）突变进行了形态学研究。这种隐性遗传、完全显性的突变特征为视网膜发育早期停滞、视神经发育不全、晶状体白内障变性和小眼症。我们描述了视杯正常发生的形态发生性细胞死亡的早期改变以及视裂形成的异常，这些改变似乎先于视网膜和视神经发育的停滞。随后视网膜中央血管的消失和白内障的形成被解释为继发现象。
