Szczeklik A
J Asthma. 1983;20 Suppl 1:23-9. doi: 10.3109/02770908309078049.
Aspirin inhibits cyclo-oxygenase by an irreversible time-dependent process of inactivation; this mechanism appears to be responsible for precipitation of asthmatic attacks in about 5%-10% of adult asthmatic patients. Besides aspirin, all other cyclo-oxygenase inhibitors induce bronchoconstriction in sensitive patients, while nonsteroidal anti-inflammatory drugs without anti-cyclo-oxygenase activity can be taken by the same patients with impunity. While aspirin-sensitive patients should avoid the potential for adverse reactions, there are rare reports of bronchodilation following ingestion of aspirin and aspirinlike drugs.
阿司匹林通过不可逆的时间依赖性失活过程抑制环氧化酶；这种机制似乎是约5%-10%的成年哮喘患者哮喘发作的诱因。除阿司匹林外，所有其他环氧化酶抑制剂都会在敏感患者中诱发支气管收缩，而无抗环氧化酶活性的非甾体抗炎药可被这些患者安全服用。虽然阿司匹林敏感患者应避免不良反应的可能性，但也有罕见的报告称，摄入阿司匹林及类阿司匹林药物后会出现支气管扩张。
