Howard J C
Metabolism. 1983 Jul;32(7 Suppl 1):41-50. doi: 10.1016/s0026-0495(83)80010-9.
The major histocompatibility complex of the rat is now called RT1, and this name is becoming widely accepted. In the past five years many recombinants have been reported within RT1 that enable distinct functional regions to be identified and located relative to each other. RT1 does not at present look particularly like its closest known relative, H-2. No doubt the genetic relationship will become apparent at the DNA level. The spontaneous diabetes mellitus of the BB rat line is associated with RT1. The data so far suggest that RT1u supplies a dominant susceptibility that becomes apparent only if protection conferred by a dominant gene mapping outside the MHC is withdrawn. It seems likely that the BB rat carries a recessive mutation at this "protective" locus.
大鼠的主要组织相容性复合体现在称为RT1，这个名称正被广泛接受。在过去五年里，已报道了许多RT1内的重组体，这些重组体使得能够确定不同的功能区域并确定它们彼此之间的位置。目前，RT1看起来与其最相近的已知亲属H-2不太相似。毫无疑问，在DNA水平上遗传关系会变得明显。BB大鼠品系的自发性糖尿病与RT1有关。目前的数据表明，RT1u提供一种显性易感性，只有当位于MHC之外的一个显性基因所赋予的保护作用被消除时，这种易感性才会显现出来。BB大鼠似乎在这个“保护”位点携带一个隐性突变。
