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大鼠纹状体中螺哌隆结合、行为变化与体内酪氨酸羟化之间的关系。

The relation between spiperone binding, behavioural changes, and in vivo tyrosine hydroxylation in the rat striatum.

作者信息

Mjörndal T, Persson S A

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1983 Mar;322(2):136-9. doi: 10.1007/BF00512386.

DOI:10.1007/BF00512386
PMID:6408490
Abstract

Spiperone 0.1-10 mg/kg i.p. increased the accumulation of Dopa in the rat striatum after Dopa decarboxylase inhibition. Approximately 50% of the rats treated with doses 1 mg/kg or higher showed cataleptic symptoms. Binding studies performed on the striatal tissues from these rats showed a dose-dependent lowering of the maximal binding of spiperone. The decrease in B max was significant at doses of spiperone 1 mg/kg or higher. Thus at 1 and 10 mg/kg, significant effects on binding, Dopa accumulation, and behaviour were found to coexist.

摘要

腹腔注射0.1 - 10毫克/千克的螺哌隆，在抑制多巴脱羧酶后可增加大鼠纹状体中多巴的蓄积。用1毫克/千克或更高剂量处理的大鼠中，约50%出现僵住症状。对这些大鼠的纹状体组织进行的结合研究表明，螺哌隆的最大结合呈剂量依赖性降低。在螺哌隆剂量为1毫克/千克或更高时，Bmax的降低具有显著性。因此，在1和10毫克/千克时，发现对结合、多巴蓄积和行为有显著影响同时存在。

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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
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Pharmakopsychiatr Neuropsychopharmakol. 1973 May;6(3):137-57. doi: 10.1055/s-0028-1094377.
3
Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase.
使用芳香族氨基酸脱羧酶抑制剂在体内同时测量大脑中酪氨酸羟化酶和色氨酸羟化酶的活性。
Naunyn Schmiedebergs Arch Pharmacol. 1972;275(2):153-68. doi: 10.1007/BF00508904.
4
A method for the determination of 3,4-dihydroxyphenylalanine (DOPA) in brain.一种测定脑中3,4-二羟基苯丙氨酸（多巴）的方法。
Naunyn Schmiedebergs Arch Pharmacol. 1972;274(3):273-80. doi: 10.1007/BF00501936.
5
Properties of [3H]haloperidol and [3H]dopamine binding associated with dopamine receptors in calf brain membranes.小牛脑膜中与多巴胺受体相关的[3H]氟哌啶醇和[3H]多巴胺结合特性
Mol Pharmacol. 1976 Sep;12(5):800-12.
6
Biochemical demonstration of dopaminergic receptors in rat and human brain using [3H]spiroperidol.使用[3H]螺哌啶醇对大鼠和人类大脑中多巴胺能受体进行生化证明。
Brain Res. 1977 Nov 18;136(3):578-84. doi: 10.1016/0006-8993(77)90084-1.
7
Striatal dopamine receptors become supersensitive while rats are geven trifluoperazine for six months.当给大鼠服用三氟拉嗪六个月时，纹状体多巴胺受体会变得超敏。
Nature. 1979 Mar 1;278(5699):59-61. doi: 10.1038/278059a0.
8
Correlation between 3H-haloperidol binding in the striatum and brain amine metabolism in the rat after treatment with neuroleptics.用抗精神病药物治疗后大鼠纹状体中3H-氟哌啶醇结合与脑胺代谢之间的相关性。
Life Sci. 1978 Aug 7;23(5):437-41. doi: 10.1016/0024-3205(78)90149-2.
9
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Biochem Pharmacol. 1978 Feb 1;27(3):307-16. doi: 10.1016/0006-2952(78)90233-2.
10
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