Torres A, Gomez P, Alonso M C, Manzanares R, Prieto B, Bayon P, Garcia-Castellano J M, Gomez-Villagran J L
Acta Haematol. 1983;70(1):63-7. doi: 10.1159/000206691.
A case of idiopathic severe aplastic anemia with spontaneous complete remission is described. Hematologic parameters normalized spontaneously 94 days after onset. However, the ability of the patient's bone marrow cells to form granulocytic-macrophagic colony-forming units (CFU-GM) or erythroid burst-forming units (BFU-E) was depressed until the 288th day, in spite of the normalization of blood counts. Incubation of the patient's bone marrow cells with antilymphocytic globulin prior to the culture experiment normalized the number of CFU-GM and BFU-E in correlated studies. Coculture of a target marrow with several concentrations of the patient's lymphocytes or serum resulted in a complete inhibition of CFU-GM. BFU-E growth was inhibited by the patient's lymphocytes, but not by serum, which rather showed burst-promoting activity. The inhibitory effect on target bone marrow persisted for 288 days, when it disappeared concomitantly with the restoration of spontaneous CFU-GM and BFU-E growth.
本文描述了一例特发性严重再生障碍性贫血自发完全缓解的病例。发病94天后血液学参数自发恢复正常。然而，尽管血细胞计数已恢复正常，但患者骨髓细胞形成粒细胞-巨噬细胞集落形成单位（CFU-GM）或红系爆式集落形成单位（BFU-E）的能力在第288天之前一直受到抑制。在培养实验前用抗淋巴细胞球蛋白孵育患者的骨髓细胞，相关研究显示CFU-GM和BFU-E的数量恢复正常。将靶骨髓与几种浓度的患者淋巴细胞或血清共培养导致CFU-GM完全抑制。BFU-E的生长受到患者淋巴细胞的抑制，但不受血清抑制，血清反而表现出爆式促进活性。对靶骨髓的抑制作用持续了288天，当它与自发CFU-GM和BFU-E生长的恢复同时消失。
