Gardiner T H
J Appl Physiol Respir Environ Exerc Physiol. 1978 Apr;44(4):576-80. doi: 10.1152/jappl.1978.44.4.576.
The pulmonary absorption of 14C-labeled urea, mannitol, inulin, and dextran was measured in vivo in anesthetized rats with alpha-naphthylthiourea (ANTU)-induced (5 mg/kg, ip) lung edema. At 1 h after ANTU treatment, the absorption of mannitol was significantly increased; in 4-h ANTU-treated animals, the absorption of urea was unchanged, whereas the absorption of mannitol, inulin and dextran was increased markedly compared to controls. Although disappearance of each solute from control lungs could be described by a single, first-order rate, absorption time curves for mannitol and inulin showed at least two components in edematous lungs: a fast component(s) and a slower, first-order component; fast-component rates for the two saccharides appeared to be similar; the slow-component rate for each compound was not significantly different from its control rate. The results suggest that fast-component absorption in ANTU-treated rats represents a fraction of instilled solute which entered damaged areas of lung where the porosity of the absorbing membranes was markedly increased, whereas slow-component absorption occurred from normal areas of lung.
在麻醉大鼠体内，用α-萘基硫脲（ANTU）诱导（5毫克/千克，腹腔注射）肺水肿，测定14C标记的尿素、甘露醇、菊粉和右旋糖酐的肺吸收情况。在ANTU处理后1小时，甘露醇的吸收显著增加；在接受ANTU处理4小时的动物中，尿素的吸收未变，而甘露醇、菊粉和右旋糖酐的吸收与对照组相比显著增加。尽管对照肺中每种溶质的消失可用单一的一级速率来描述，但水肿肺中甘露醇和菊粉的吸收时间曲线显示至少有两个成分：一个快速成分和一个较慢的一级成分；两种糖类的快速成分速率似乎相似；每种化合物的慢速成分速率与其对照速率无显著差异。结果表明，ANTU处理大鼠的快速成分吸收代表了注入溶质的一部分，这部分溶质进入了肺的受损区域，在那里吸收膜的孔隙率显著增加，而慢速成分吸收则发生在肺的正常区域。
