Younes M, Youssef M
J Appl Physiol Respir Environ Exerc Physiol. 1978 Apr;44(4):596-606. doi: 10.1152/jappl.1978.44.4.596.
The effect of halothane, fentanyl, Innovar, thiopental, and ketamine on inspiratory output, vagal influence, and chest wall reflex was assessed in seven cats lightly anesthetized with pentobarbital, using the method of airway occlusion with and without rapid vagal cooling. All anesthetics depressed inspiratory output, as expressed by deltaP/deltat, of the first occluded inspiration. However, only halothane depressed peak inspiratory output (Pmax). Phasic vagal influence was markedly depressed by 2% halothane but was preserved under other anesthetics. The ability to induce tonic vagal influence (expiratory muscle recruitment) was lost under halothane. Inspiratory inhibitory chest wall reflex was evident in two cats during airway occlusion. Addition of any test anesthetic abolished the reflex. It is concluded that halothane should be avoided in studies dealing with assessment of vagal influence.
在七只用戊巴比妥轻度麻醉的猫中，采用气道阻塞法并结合快速迷走神经降温与不降温的方式，评估了氟烷、芬太尼、氟哌利多芬太尼合剂、硫喷妥钠和氯胺酮对吸气输出、迷走神经影响及胸壁反射的作用。所有麻醉药均降低了首次阻塞吸气时以△P/△t表示的吸气输出。然而，只有氟烷降低了最大吸气输出（Pmax）。2%氟烷显著抑制了阶段性迷走神经影响，但在其他麻醉药作用下该影响得以保留。在氟烷作用下，诱导紧张性迷走神经影响（呼气肌募集）的能力丧失。在气道阻塞期间，两只猫出现了吸气抑制性胸壁反射。添加任何一种受试麻醉药均可消除该反射。得出的结论是，在涉及迷走神经影响评估的研究中应避免使用氟烷。
