Jeannoda V L, Creppy E E, Beck G, Dirheimer G
C R Seances Acad Sci III. 1983;296(7):335-8.
A dialysable and thermostable compound was partially purified from Cnestis glabra (Connaracea) seeds. It is insoluble in organic solvents. At a dose corresponding to 0.5 g of seeds it has a lethal effect on mice after convulsive attacks. Sodium dipropylacetate, an anticonvulsive agent prevents the convulsions but not the death of the animals. The toxic compound inhibits protein synthesis in a rabbit reticulocyte lysate and in hepatoma tissue culture; moreover in the cell culture, the incorporation of thymidine into DNA is inhibited.
从光滑金钩花（牛栓藤科）种子中部分纯化出一种可透析且耐热的化合物。它不溶于有机溶剂。剂量相当于0.5克种子时，它在引起惊厥发作后对小鼠具有致死作用。抗惊厥药二丙基乙酸钠可防止惊厥，但不能防止动物死亡。该有毒化合物抑制兔网织红细胞裂解物和肝癌组织培养中的蛋白质合成；此外，在细胞培养中，胸苷掺入DNA的过程也受到抑制。
