Pointon R C, Askill C, Hunter R D, Wilkinson P M
Clin Radiol. 1983 Jul;34(4):459-62. doi: 10.1016/s0009-9260(83)80246-3.
A pilot study of synchronous methotrexate and radiation therapy was carried out in 50 patients with advanced carcinoma of the head and neck, of whom 48 were assessable for response. Complete resolution of disease, maintained for 2 years, was achieved in 21 patients (45%), and in 19 out of 36 patients (53%) with carcinoma of the oropharynx and hypopharynx. The treatment was well tolerated, with acceptable morbidity.
对50例晚期头颈癌患者进行了甲氨蝶呤与放疗同步进行的初步研究，其中48例可评估疗效。21例患者（45%）实现了疾病完全消退，并维持2年，在36例口咽和下咽癌患者中有19例（53%）实现了疾病完全消退。该治疗耐受性良好，发病率可接受。
