Tannenbaum G S, Eikelboom R, Ling N
Endocrinology. 1983 Sep;113(3):1173-5. doi: 10.1210/endo-113-3-1173.
Lesions of the ventromedial-arcuate (VMH-ARC) region of the hypothalamus result in impaired growth accompanied by a marked suppression in spontaneous GH secretory bursts. We studied the effects of an analog of the recently characterized human pancreas GH-releasing factor hpGRF(1-40) on GH secretory dynamics in freely-moving chronically cannulated rats bearing electrolytic lesions of the VMH-ARC. Intravenous administration of the hpGRF analog (hpGRFa) caused a dramatic surge of GH within 5 min; plasma GH levels rose to values as high as 2900 ng/ml and remained significantly elevated for 15-30 min post treatment. The simultaneous iv administration of somatostatin-14 and hpGRFa resulted in a significant inhibition of the hpGRFa-induced GH release at 5 min but not at 15 min. These results clearly demonstrate that impaired GH secretion resulting from VMH-ARC lesions can be restored by hpGRF. The findings are promising in that hpGRF and its analogs may provide valuable agents for the diagnosis and treatment of disorders of growth secondary to CNS dysfunction.
下丘脑腹内侧 - 弓状核（VMH - ARC）区域的损伤会导致生长受损，并伴有自发性生长激素（GH）分泌脉冲的显著抑制。我们研究了最近鉴定出的人胰腺生长激素释放因子hpGRF(1 - 40)的类似物对患有VMH - ARC电解损伤的自由活动的慢性插管大鼠生长激素分泌动力学的影响。静脉注射hpGRF类似物（hpGRFa）在5分钟内导致生长激素急剧激增；血浆生长激素水平升至高达2900 ng/ml，并在治疗后15 - 30分钟内保持显著升高。同时静脉注射生长抑素 - 14和hpGRFa在5分钟时导致对hpGRFa诱导的生长激素释放有显著抑制，但在15分钟时没有。这些结果清楚地表明，VMH - ARC损伤导致的生长激素分泌受损可以通过hpGRF恢复。这些发现很有前景，因为hpGRF及其类似物可能为诊断和治疗继发于中枢神经系统功能障碍的生长紊乱提供有价值的药物。
