Debbas N M, Du Cailar C, Sassine A, Derancourt J, Demaille J G, Puech P
Eur J Clin Invest. 1983 Apr;13(2):123-7. doi: 10.1111/j.1365-2362.1983.tb00076.x.
A study of plasma and cardiac concentrations of amiodarone during the course of long-term oral therapy was made possible by the improvement of analytical high performance liquid chromatography of plasma and tissue extracts. The plasma level was found to increase linearly with the daily dose of the drug, above a threshold value of c. 1 . 9 mg kg-1 day-1. Similarly, the cardiac content increased linearly with the daily dose, with no threshold, showing that the drug is taken up and accumulated in the cardiac tissue, with no obvious difference between atrial and ventricular samples (P greater than 0 . 05). Both plasma and heart showed no saturation at high drug intake, a justification for increasing the oral intake in severe cases. The linear relationship between tissue and blood concentrations allows a prediction of the cardiac level from a simple and routine blood analysis.
高效液相色谱法对血浆和组织提取物分析的改进，使得对长期口服治疗过程中胺碘酮的血浆和心脏浓度进行研究成为可能。血浆水平在约1.9mg·kg⁻¹·d⁻¹的阈值以上，随药物日剂量呈线性增加。同样，心脏中的药物含量也随日剂量呈线性增加，无阈值，表明该药物在心脏组织中摄取和蓄积，心房和心室样本之间无明显差异（P>0.05）。在高药物摄入量时，血浆和心脏均未出现饱和现象，这为在严重病例中增加口服剂量提供了依据。组织与血液浓度之间的线性关系使得通过简单常规的血液分析就能预测心脏中的药物水平。
