Adachihara A
Haemostasis. 1983;13(2):78-82. doi: 10.1159/000214707.
Huang-lien-chieh-tu-tang (HLCT) extract was given orally to a patient with severe hemophilia A. The plasma concentration of factor VIII rose from less than 1 to 41% 1 h after oral administration of HLCT extract. APTT also decreased from 102.0 to 70.9 s. In vitro experiments, HLCT showed factor VIII, IX and X biological activity at concentrations around 0.08%. There was no factor-VIII-antigen-related activity in HLCT.
将黄连解毒汤提取物口服给予一名重度甲型血友病患者。口服黄连解毒汤提取物1小时后，血浆中凝血因子VIII的浓度从低于1%升至41%。活化部分凝血活酶时间（APTT）也从102.0秒降至70.9秒。在体外实验中，黄连解毒汤在浓度约为0.08%时显示出凝血因子VIII、IX和X的生物活性。黄连解毒汤中不存在与凝血因子VIII抗原相关的活性。
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