van der Schoot P, de Greef W J
J Endocrinol. 1983 Aug;98(2):227-32. doi: 10.1677/joe.0.0980227.
The suckling stimulus exerts an inhibitory action on the release of gonadotrophins during lactation. The possible involvement of the adrenal glands in this process was examined by studying the plasma levels of gonadotrophins in lactating rats ovariectomized on the day after parturition. It appeared that the suppression, throughout suckling, of the rise in levels of gonadotrophins in blood after ovariectomy occurred to the same extent in adrenalectomized and in sham-operated animals. It thus seems unlikely that adrenocortical hormones, albeit secreted in larger quantities during lactation, exert an inhibitory effect on the release of gonadotrophins. Adrenalectomy had a marked effect on the plasma concentrations of prolactin during the second half of lactation. Whereas plasma concentrations of prolactin in the first half of lactation were similar in adrenalectomized and sham-operated rats, the concentrations in adrenalectomized rats did not undergo the reduction found in sham-operated rats. Adrenal hormones may thus be involved in the reduction of blood levels of prolactin observed in rats and in other mammals as lactation progresses.
哺乳刺激在哺乳期对促性腺激素的释放起抑制作用。通过研究产后次日切除卵巢的泌乳大鼠的促性腺激素血浆水平，探讨了肾上腺在此过程中可能的作用。结果显示，在整个哺乳期间，切除卵巢后血液中促性腺激素水平的升高受到抑制，在肾上腺切除的动物和假手术动物中程度相同。因此，尽管在哺乳期肾上腺皮质激素分泌量增加，但它们似乎不太可能对促性腺激素的释放产生抑制作用。肾上腺切除术对哺乳期后半段催乳素的血浆浓度有显著影响。在哺乳期前半段，肾上腺切除的大鼠和假手术大鼠的催乳素血浆浓度相似，但肾上腺切除的大鼠的浓度并未像假手术大鼠那样降低。因此，随着哺乳期的进展，肾上腺激素可能参与了大鼠和其他哺乳动物血液中催乳素水平的降低。
