Schramme C, Denef C
Neuroendocrinology. 1983 Jun;36(6):483-5. doi: 10.1159/000123502.
Superfusion of rat anterior pituitary cell aggregates with 10-min pulses of 0.1-10 nM angiotensin II (AII) resulted in a prompt and concentration-dependent rise of PRL release. The effect could be blocked by saralasin, an AII receptor antagonist. The response to AII, but not that to TRH, was rapidly desensitized: a 10 nM AII pulse caused an 80% depression of the response to a subsequent 10 nM pulse given 50 min later. The data provide a possible functional significance for the renin-angiotensin system recently demonstrated in the anterior pituitary.
用0.1 - 10 nM血管紧张素II（AII）对大鼠垂体前叶细胞聚集体进行10分钟的脉冲灌流，会导致催乳素（PRL）释放迅速且呈浓度依赖性升高。该效应可被AII受体拮抗剂沙拉新阻断。对AII的反应迅速脱敏，而对促甲状腺激素释放激素（TRH）的反应则不然：10 nM AII脉冲会使50分钟后给予的后续10 nM脉冲的反应降低80%。这些数据为最近在前垂体中发现的肾素 - 血管紧张素系统提供了一种可能的功能意义。
