Seeger W, Wolf H R, Stähler G, Neuhof H
Respiration. 1983;44(4):273-81. doi: 10.1159/000194558.
In a model of isolated, ventilated and perfused rabbit lungs the influence of a fixed amount of edema (standardized at 7 g weight gain/kg body weight) on the pressure-volume characteristics of the isolated lungs was investigated. Periodical stimulation with A 23187 or A 23187 plus indomethacin or A 23187 plus indomethacin plus glutathione evokes an increase in vascular permeability with subsequent severe alterations of the pressure-volume characteristics, reflecting a disturbance in the alveolar surfactant system, which is more extensive the more rapidly the edema develops. The alterations caused this way are markedly more severe than those caused by the same amount of weight gain due to mechanically increased capillary filtration pressure.
在一个离体、通气和灌注的兔肺模型中，研究了固定量水肿（标准化为体重增加7 g/kg）对离体肺压力-容积特性的影响。用A 23187或A 23187加吲哚美辛或A 23187加吲哚美辛加谷胱甘肽进行周期性刺激会引起血管通透性增加，随后压力-容积特性发生严重改变，这反映了肺泡表面活性物质系统的紊乱，水肿发展得越快，这种紊乱就越广泛。通过这种方式引起的改变明显比由于机械性增加毛细血管滤过压导致相同体重增加所引起的改变更严重。
