Interdigitating reticulum cell and lymphoproliferative disease: possible correlations between skin and thymus-dependent lymphocyte system revisited.

Three cases of primary cutaneous T-cell lymphoma non-Sézary and non-mycosis fungoides are described, in which ultrastructural investigations revealed the presence of interdigitating reticulum cell in the skin infiltrate. The cytological finding is discussed in light of the immunological function hypothetically performed by the skin.