Bernocchi G, Scherini E
Acta Histochem. 1983;72(1):1-14. doi: 10.1016/S0065-1281(83)80003-8.
The histochemical detection of SSADH activity corroborates some crucial steps of the maturation of Purkinje neurons in rat cerebellum. The SSADH-specific activity seems to appear early, within the first week of postnatal life, in a few Purkinje cells. Around the 12th day most cells were SSADH positive, even if some were still negative. This period is an important step of postnatal histogenesis when many histological and physiological data show important neuronal changes. At the end of cerebellar histogenesis the SSADH activity showed the same pattern as in adult rats. Our findings suggest that in the Purkinje cell population the maturation does not occur simultaneously thus confirming the concept of "heterogeneity" (different functional states).
对SSADH活性的组织化学检测证实了大鼠小脑浦肯野神经元成熟的一些关键步骤。SSADH特异性活性似乎在出生后第一周内就早期出现在少数浦肯野细胞中。在第12天左右，大多数细胞呈SSADH阳性，即使仍有一些细胞呈阴性。这一时期是出生后组织发生的重要阶段，许多组织学和生理学数据显示出重要的神经元变化。在小脑组织发生结束时，SSADH活性呈现出与成年大鼠相同的模式。我们的研究结果表明，在浦肯野细胞群体中，成熟并非同时发生，从而证实了“异质性”（不同功能状态）的概念。
