Quisling R G, Mickle J P, Ballinger W
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):369-73.
An animal model for a high-flow, aorta-to-vena cava fistula has been developed using microsurgical techniques in the rat. This model provides a means for histopathologic and angiographic evaluation of the natural evolution of major vessel, artery to vein fistulae. Data obtained from such a model may have relevance to the successful treatment of high-flow, head and neck fistulae using detachable intraarterial occlusive balloons. This microsurgical technique is unique, since it requires no intervening sutures or graft material that would alter the histopathologic process. After a series of such aortocaval fistulae were created, serial histologic and angiographic features were elucidated for intervals between 1 day and 6 months. Three stages of evolution are noted including: an initial hemorrhagic dissection phase; a subacute phase where organization of the thrombus and actual formation of a fistulous tract occurs; and a chronic phase characterized by pseudoaneurysm formation, arterialization of the vena cava, and proximal vasodilatation of the aorta.
利用大鼠的显微外科技术建立了一种高流量主动脉至腔静脉瘘的动物模型。该模型为大动脉、动脉至静脉瘘自然演变的组织病理学和血管造影评估提供了一种方法。从该模型获得的数据可能与使用可脱性动脉内闭塞球囊成功治疗高流量头颈部瘘有关。这种显微外科技术很独特，因为它不需要会改变组织病理过程的介入缝线或移植材料。在创建了一系列此类主动脉腔静脉瘘后，阐明了1天至6个月期间的系列组织学和血管造影特征。注意到三个演变阶段，包括：初始出血性剥离期；血栓机化和瘘管实际形成的亚急性期；以及以假性动脉瘤形成、腔静脉动脉化和主动脉近端血管扩张为特征的慢性期。
