Adam P, Fabre N, Guell A, Bessoles G, Roulleau J, Bès A
AJNR Am J Neuroradiol. 1983 May-Jun;4(3):442-5.
Thirty-seven patients with Parkinson disease were evaluated clinically and with computed tomography in order to determine the incidence of prefrontal atrophy. An age-matched healthy control group was also scanned. The computed tomographic criteria used were the width of cortical sulci and ventriculocerebral indices. Parkinsonian patients with frontal cortical atrophy represent only one patient out of three. They are much older than parkinsonian patients with normal computed tomographic scans, and the onset of their illness occurs later. No significant difference was found according to gender, parkinsonian clinical triad, psychomotor study, or mean duration of illness and/or dopatherapy to the time of computed tomography. This work seems to separate two Parkinson diseases: one beginning before 65 years and damaging the nigrostriate system, and another beginning after 65 years and damaging both the nigrostriate system and the cortex, particularly the frontal cortex.
为了确定前额叶萎缩的发生率，对37例帕金森病患者进行了临床评估和计算机断层扫描。还对年龄匹配的健康对照组进行了扫描。所采用的计算机断层扫描标准为皮质沟宽度和脑室脑指数。额叶皮质萎缩的帕金森病患者仅占三分之一。他们比计算机断层扫描正常的帕金森病患者年龄大得多，且发病较晚。根据性别、帕金森病临床三联征、精神运动研究，或疾病和/或多巴胺治疗的平均持续时间至计算机断层扫描时，未发现显著差异。这项研究似乎区分出了两种帕金森病：一种始于65岁之前，损害黑质纹状体系统；另一种始于65岁之后，损害黑质纹状体系统和皮质，尤其是额叶皮质。
