锂会干扰利血平引起的多巴胺耗竭。
Lithium interferes with reserpine-induced dopamine depletion.
作者信息
Reches A, Hassan M N, Jackson V, Fahn S
出版信息
Ann Neurol. 1983 Jun;13(6):671-3. doi: 10.1002/ana.410130617.
PMID:6410976
Abstract
Long-term lithium treatment attenuated the hypokinetic effect of reserpine in a patient with tardive dyskinesia. In rats, prophylactic lithium administration inhibits reserpine-induced dopamine depletion in the brain. These data indicate that lithium may limit the therapeutic efficacy of reserpine in tardive dyskinesia.
摘要
长期锂盐治疗减轻了利血平对一名迟发性运动障碍患者的运动减退作用。在大鼠中，预防性给予锂盐可抑制利血平诱导的脑内多巴胺耗竭。这些数据表明锂盐可能会限制利血平在迟发性运动障碍中的治疗效果。
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